Seminar

Abstract

In this talk, I will review two research topics that my group has been working on: neural interface technologies and cellular interface microchips. The first topic covers the evolution of Michigan neural probe technologies toward scaling up the number of recording sites, enhancing the recording reliability, and introducing multi-modalities in neural interface. We investigated scaling of probe geometry to reduce probe surface area in the form of lattice probes, while exploring polymer materials for providing flexibility in the shank body to reduce micromotion effects. As a part of multi-modality, we monolithically integrated optical waveguides on the Michigan probe to bring optical stimulation capability in addition to electrical recording for optogenetics study.
The second topic covers the microfluidic platforms that my group has developed for robust single cell capture, long-term clonal culture of heterogeneous single cells for drug screening and differentiation study, and selective cell retrieval for further phenotypic and genotypic analysis. A growing body of evidence supports the presence of cancer “stem-like” cells (CSC) in many cancers. In the CSC model only a limited subset of the heterogeneous population actually retains the ability initiate new tumors, grow, and metastasize. Understanding and analyzing this heterogeneity at single cell level is important to improve our basic understanding of cancer biology. The developed platform grants orders of magnitude higher throughput in analyzing single cells than conventional methods. Single-cell retrieval technique will be introduced to selectively release the target single cells with high precision, allowing for characterizing single cell genotype after observing, in assays, the phenotypic responses of the cells.
 

Bio

Euisik Yoon received the B.S. and M.S. degrees in electronics engineering from Seoul National University in 1982 and 1984, respectively, and the Ph.D. degree in electrical engineering from the University of Michigan, Ann Arbor, in 1990.
From 1990 to 1994 he worked for the Fairchild Research Center of the National Semiconductor Corp. in Santa Clara, CA, where he engaged in researching deep submicron CMOS integration and advanced gate dielectrics. From 1994 to 1996 he was a Member of the Technical Staff at Silicon Graphics Inc. in Mountain View, CA, where he worked on the design of the MIPS microprocessor R4300i and the RCP 3-D graphic coprocessor. He took faculty positions in the Department of Electrical Engineering at Korea Advanced Institute of Science and Technology (KAIST) in Daejon, Korea (1996-2005) and in the Department of Electrical and Computer Engineering at the University of Minnesota, Minneapolis, MN (2005-2008), respectively. During the academic year of 2000-2001, he was a Visiting Faculty at Agilent Laboratory, Palo Alto, CA. In 2008, he joined the Department of Electrical Engineering and Computer Science at the University of Michigan, Ann Arbor, MI, where he is a Professor and the Director of NSF International Program for the Advancement of Neurotechnology. He served as the Director of Lurie Nanofabrication Facility at the University of Michigan from 2011 to 2016. His research interests are in MEMS, integrated microsystems, and VLSI circuit design.
Dr. Yoon was the co-recipient of the Student Paper Award at the IEEE International Microwave Symposium in 1999 and 2000, respectively. He has served on various Technical Program Committees including the Microprocesses and Nanotechnology Conference (1998), the International Sensor Conference (2001), the IEEE Asia-Pacific Conference on Advanced System Integrated Circuits (2001-2002), the International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) (2003, 2005), the IEEE International Electron Device Meeting (2006-2008) and the IEEE International Conference on Micro Electro Mechanical Systems (2006, 2009-2010). He also served on the IEEE International Solid-State Circuit Conference program committee (2003-2007) and was a general chair of International Symposium on Bio Micro & Nanosystems (2005).